Monday, April 29, 2013

Germ-zapping 'robots': Hospitals combat superbugs

Using ultraviolet light, a machine disinfects a hospital room at the Westchester Medical Center in Valhalla, N.Y., Wednesday, March 20, 2013. (AP Photo/Seth Wenig)

Using ultraviolet light, a machine disinfects a hospital room at the Westchester Medical Center in Valhalla, N.Y., Wednesday, March 20, 2013. (AP Photo/Seth Wenig)

Michael Claes, 62, who contracted a superbug while in the hospital, poses for a photograph while recovering at home in New York, Monday, April 8, 2013. Claes caught a bad case of a diarrheal illness caused by Clostridium dificile, while he was a kidney patient last fall at New York City's Lenox Hill Hospital. (AP Photo/Kathy Willens)

Michael Claes, 62, who contracted a superbug while in the hospital, shows a bottle of one of his daily medications on Monday, April 8, 2013 as he recovers at home in New York. Claes caught a bad case of a diarrheal illness caused by Clostridium dificile, while he was a kidney patient at New York City's Lenox Hill Hospital in fall 2012. (AP Photo/Kathy Willens)

Using ultraviolet light, a machine disinfects a hospital room at the Westchester Medical Center in Valhalla, N.Y., Wednesday, March 20, 2013. (AP Photo/Seth Wenig)

Using ultraviolet light, a machine disinfects a hospital room at the Westchester Medical Center in Valhalla, N.Y., Wednesday, March 20, 2013. (AP Photo/Seth Wenig)

NEW YORK (AP) ? They sweep. They swab. They sterilize. And still the germs persist.

In U.S. hospitals, an estimated 1 in 20 patients pick up infections they didn't have when they arrived, some caused by dangerous 'superbugs' that are hard to treat.

The rise of these superbugs, along with increased pressure from the government and insurers, is driving hospitals to try all sorts of new approaches to stop their spread:

Machines that resemble "Star Wars" robots and emit ultraviolet light or hydrogen peroxide vapors. Germ-resistant copper bed rails, call buttons and IV poles. Antimicrobial linens, curtains and wall paint.

While these products can help get a room clean, their true impact is still debatable. There is no widely-accepted evidence that these inventions have prevented infections or deaths.

Meanwhile, insurers are pushing hospitals to do a better job and the government's Medicare program has moved to stop paying bills for certain infections caught in the hospital.

"We're seeing a culture change" in hospitals, said Jennie Mayfield, who tracks infections at Barnes-Jewish Hospital in St. Louis.

Those hospital infections are tied to an estimated 100,000 deaths each year and add as much as $30 billion a year in medical costs, according to the Centers for Disease Control and Prevention. The agency last month sounded an alarm about a "nightmare bacteria" resistant to one class of antibiotics. That kind is still rare but it showed up last year in at least 200 hospitals.

Hospitals started paying attention to infection control in the late 1880s, when mounting evidence showed unsanitary conditions were hurting patients. Hospital hygiene has been a concern ever since, with a renewed emphasis triggered by the emergence a decade ago of a nasty strain of intestinal bug called Clostridium difficile, or C-diff.

The diarrhea-causing C-diff is now linked to 14,000 U.S. deaths annually. That's been the catalyst for the growing focus on infection control, said Mayfield, who is also president-elect of the Association for Professionals in Infection Control and Epidemiology.

C-diff is easier to treat than some other hospital superbugs, like methicillin-resistant staph, or MRSA, but it's particularly difficult to clean away. Alcohol-based hand sanitizers don't work and C-diff can persist on hospital room surfaces for days. The CDC recommends hospital staff clean their hands rigorously with soap and water ? or better yet, wear gloves. And rooms should be cleaned intensively with bleach, the CDC says.

Michael Claes developed a bad case of C-diff while he was a kidney patient last fall at New York City's Lenox Hill Hospital. He and his doctor believe he caught it at the hospital. Claes praised his overall care, but felt the hospital's room cleaning and infection control was less than perfect.

"I would use the word 'perfunctory,'" he said.

Lenox Hill spokeswoman Ann Silverman disputed that characterization, noting hospital workers are making efforts that patients often can't see, like using hand cleansers dispensers in hallways. She ticked off a list of measure used to prevent the spread of germs, ranging from educating patients' family members to isolation and other protective steps with each C-diff patient.

The hospital's C-diff infection rate is lower than the state average, she said.

Westchester Medical Center, a 643-bed hospital in the suburbs of New York City has also been hit by cases of C-diff and the other superbugs.

Complicating matters is the fact that larger proportions of hospital patients today are sicker and more susceptible to the ravages of infections, said Dr. Marisa Montecalvo, a contagious diseases specialist at Westchester.

There's a growing recognition that it's not only surgical knives and operating rooms that need a thorough cleaning but also spots like bed rails and even television remote controls, she said. Now there's more attention to making sure "that all the nooks and crannies are clean, and that it's done in as perfect a manner as can be done," Montecalvo said.

Enter companies like Xenex Healthcare Services, a San Antonio company that makes a portable, $125,000 machine that's rolled into rooms to zap C-diff and other bacteria and viruses dead with ultraviolet light. Xenex has sold or leased devices to more than 100 U.S. hospitals, including Westchester Medical Center.

The market niche is expected to grow from $30 million to $80 million in the next three years, according to Frost & Sullivan, a market research firm.

Mark Stibich, Xenex's chief scientific officer, said client hospitals sometimes call them robots and report improved satisfaction scores from patients who seem impressed that the medical center is trotting out that kind of technology.

At Westchester, workers still clean rooms, but the staff appreciates the high-tech backup, said housekeeping manager Carolyn Bevans.

"We all like it," she said of the Xenex.

At Cooley Dickinson Hospital, a 140-bed facility in Northampton, Mass., the staff calls their machines Thing One, Thing Two, Thing Three and Thing Four, borrowing from the children's book "The Cat in the Hat."

But while the things in the Dr. Seuss tale were house-wrecking imps, Cooley Dickinson officials said the ultraviolet has done a terrific job at cleaning their hospital of the difficult C-diff.

"We did all the recommended things. We used bleach. We monitored the quality of cleaning," but C-diff rates wouldn't budge, said nurse Linda Riley, who's in charge of infection prevention at Cooley Dickinson.

A small observational study at the hospital showed C-diff infection rates fell by half and C-diff deaths fell from 14 to 2 during the last two years, compared to the two years before the machines.

Some experts say there's not enough evidence to show the machines are worth it. No national study has shown that these products have led to reduced deaths or infection rates, noted Dr. L. Clifford McDonald of the Centers for Disease Control and Prevention.

His point: It only takes a minute for a nurse or visitor with dirty hands to walk into a room, touch a vulnerable patient with germy hands, and undo the benefits of a recent space-age cleaning.

"Environments get dirty again," McDonald said, and thorough cleaning with conventional disinfectants ought to do the job.

Beyond products to disinfect a room, there are tools to make sure doctors, nurses and other hospital staff are properly cleaning their hands when they come into a patient's room. Among them are scanners that monitor how many times a health care worker uses a sink or hand sanitizer dispenser.

Still, "technology only takes us so far," said Christian Lillis, who runs a small foundation named after his mother who died from a C-diff infection.

Lillis said the hospitals he is most impressed with include Swedish Covenant Hospital in Chicago, where thorough cleanings are confirmed with spot checks. Fluorescent powder is dabbed around a room before it's cleaned and a special light shows if the powder was removed. That strategy was followed by a 28 percent decline in C-diff, he said.

He also cites Advocate Christ Medical Center in Oak Lawn, Ill., where the focus is on elbow grease and bleach wipes. What's different, he said, is the merger of the housekeeping and infection prevention staff. That emphasizes that cleaning is less about being a maid's service than about saving patients from superbugs.

"If your hospital's not clean, you're creating more problems than you're solving," Lillis said.

___

Online:

CDC: http://www.cdc.gov/hai/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-04-29-Disinfecting%20Robots/id-c6086ee111ef471fab7ab8279c9a196e

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Celts top Knicks 97-90 in OT, avoid playoff sweep

New York Knicks forward Carmelo Anthony (7) shoots against Boston Celtics forwards Paul Pierce (34) and Brandon Bass (30) during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

New York Knicks forward Carmelo Anthony (7) shoots against Boston Celtics forwards Paul Pierce (34) and Brandon Bass (30) during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

New York Knicks forward Carmelo Anthony, left, makes a move against the defense of Boston Celtics forward Paul Pierce during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

Boston Celtics center Kevin Garnett, right, has words with New York Knicks' Kenyon Martin during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

Boston Celtics center Kevin Garnett, second from left, pulls down an offensive rebound against New York Knicks forward Quentin Richardson (55), forward Kenyon Martin (3) and forward Steve Novak (16) during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

Boston Celtics forward Paul Pierce (34) drives between New York Knicks point guard Raymond Felton (2) and center Tyson Chandler (6) on his way to scoring a basket during the first half in Game 4 of a first-round NBA basketball playoff series in Boston, Sunday, April 28, 2013. (AP Photo/Elise Amendola)

(AP) ? The reeling Boston Celtics needed a spark of optimism and a surge of offense to keep their season going.

Jason Terry provided both.

The energetic guard who had struggled in the first three games cheered his teammates up when the Knicks were rallying, then scored the Celtics' last nine points in a 97-90 overtime win Sunday over the New York Knicks that avoided a four-game sweep.

"He's just one of those guys you want around your team, whether he's playing or not," Boston coach Doc Rivers said. "He brings sunshine."

And when he's playing well, he's hitting jumpers, even in the most critical situations.

"As long as there's time on the clock, as long as there is another game, it's an opportunity to do something special," Terry said.

That opportunity was slipping away when the Knicks overcame a 59-39 deficit early in the third quarter and took an 84-82 lead on Raymond Felton's jumper with 1:18 left in regulation. But Kevin Garnett hit a 16-footer jumper to tie the game 11 seconds later.

In overtime, Terry gave the Celtics the lead for good, 91-88, with a 3-pointer with 1:32 remaining.

Now he has another opportunity in New York in Game 5 on Wednesday night as the Celtics work toward becoming the first team in NBA history to win a series after trailing 3-0.

"We have to come out with the exact same aggression," Jeff Green said. "We just have to play every possession, every defensive possession, like it's our last."

But the Knicks still have a big advantage as they try for their first playoff series win in 13 years. All they need is one win out of a possible three games.

"We didn't shoot the ball well today at all and we still put ourselves in a position to win," said Carmelo Anthony, who led all scorers with 36 points but missed 25 of his 35 shots. "We're going back home with a lot of confidence."

Especially with J.R. Smith returning.

The NBA's Sixth Man of the Year was suspended for Sunday's game after hitting Terry with his elbow in New York's 90-76 win on Friday night. He scored 49 points in the first three games.

"We didn't make the plays coming down the home stretch. They did," Knicks coach Mike Woodson said. "J.R. is a big piece of what we do, but he wasn't here ... so I'm not using that as an excuse."

Terry was angry after being hit in the face by Smith, but something more important motivated him.

"It wasn't really the elbow," he said. "It was more (like) this is it. I mean, the season's over. You can leave it all out here tonight and go home for a long summer or you can live to play another day."

He conceded that his nose "still hurts right now. As long as I feel that, I guess I'll be thinking about it."

Paul Pierce led Boston with 29 points, Green added 26 and Terry had 18.

Felton scored 27 for New York two days after their Game 3 win in Boston.

"We did our job when we came here. We got us a win," he said. "That was our goal."

The Knicks made just 28.9 percent of their shots in falling behind 54-35 at halftime. But they tied it at 74 with 7:16 left in the fourth quarter on a layup by Iman Shumpert.

"We're a veteran ballclub so we don't panic," Jason Kidd said. "We had a great opportunity and we just couldn't close the door."

Garnett expected that.

"Good teams are going to make those runs," he said. "It's deflating, but we kept fighting. We found a way to get over the hump."

After Terry put Boston ahead 91-88 in overtime, Anthony made a fadeaway shot with 1:17 remaining. Then Terry sank a 15-footer that made it 93-90 with 50 seconds remaining.

Anthony followed with an off-target 3-pointer with 21 seconds to go and Terry was fouled by Steve Novak. He made both free throws then added a layup to close out the game. It came just in time for a player who failed to score in Game 1 for the first time in 88 playoff games.

"I had every intention of trying to make an impact on the game," Terry said. "If I wasn't making shots, I wanted to get a steal, get a rebound, any little thing to keep it going. Again, I'm going to coach AAU, but I don't want to do that right now."

The Celtics showed renewed energy early after being held below 80 points in each of the first three games. They were more aggressive and more physical than they had been.

"We knew they were going to come out like that," Anthony said. "They were fighting for dear life."

With leaders such as Pierce and Garnett, the Celtics have "tremendous" pride, Terry said. "Getting swept is something that no man that's been in this league that long wants to do. It's disheartening.

"Now we have to go into a hostile environment and they're going to be trying to get it over with. They don't want to come back here, but we do."

NOTES: Garnett finished with 13 points, 17 rebounds and six assists. ... The Knicks went 7 for 30 on 3-point shots. ... Boston had just three offensive rebounds while the Knicks grabbed 16. ... The Celtics have been swept six times in the 112 playoff series in their history. ... The Knicks were 19-2 in their previous 21 games. The Celtics were 5-14 in their previous 19. ... For the Celtics, Garnett, Green and Brandon Bass each had four fouls five minutes into the third quarter. Bass committed his fifth with 5:10 left in the period and fouled out with 4:27 to go in the game. ... Anthony committed his fourth with 4:08 remaining in the third.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-29-BKN-Knicks-Celtics-Folo/id-beed69074c3643a38201d3e3238244d8

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Spotify Quietly Starts Rolling Out The Discover Tab In Its Web App, First In The UK And Nordics

spotify discoverBack in December 2012, music streaming service Spotify provided an update on how it was going to double down on social recommendations to increase music listening on its platform by launching two new features, Follow and Discover. While the Follow feature, aimed at friends, started to get rolled out in March and April, it turns out that Spotify has also been rolling out the Discover feature.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Ao4VYFaow1Q/

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Sunday, April 28, 2013

Miss. man charged in ricin letters case

BRANDON, Miss. (AP) ? A Mississippi man was charged Saturday with making and possessing ricin for use as a weapon as part of the investigation into poison-laced letters sent to President Barack Obama and others, authorities said.

U.S. attorney Felicia Adams and Daniel McMullen, the FBI agent in charge in Mississippi, made the announcement in news release Saturday following the arrest of 41-year-old James Everett Dutschke.

FBI spokeswoman Deborah Madden said Dutschke (pronounced DUHS'-kee) was arrested about 12:50 a.m. Saturday at his house in Tupelo.

The letters, which tests showed were tainted with ricin, were sent April 8 to President Barack Obama, Sen. Roger Wicker of Mississippi and 80-year-old Mississippi judge, Sadie Holland.

Dutschke is expected to appear Monday in U.S. District Court in Oxford.

He faces up to life in prison, if convicted.

The news release said Dutschke was charged with "knowingly developing, producing, stockpiling, transferring, acquiring, retaining and possessing a biological agent, toxin and delivery system, for use as a weapon, to wit: ricin."

Dutschke's house, business and vehicles were searched earlier in the week and he had been under surveillance.

Dutschke's attorney, Lori Nail Basham, said Saturday in a text message that "the authorities have confirmed Mr. Dutschke's arrest. We have no comment at this time."

Basham said earlier this week that Dutschke was "cooperating fully" with investigators. Dutschke has insisted he had nothing to do with the letters.

Ryan Taylor, a spokesman for Wicker, said Saturday that "because the investigation is still ongoing, we're not able to comment."

Charges in the case were initially filed against an Elvis impersonator but then dropped. Attention then turned to Dutschke, who has ties to the former suspect, the judge and the senator. Earlier in the week, as investigators searched his primary residence in Tupelo, Dutschke told The Associated Press, "I don't know how much more of this I can take."

"I'm a patriotic American. I don't have any grudges against anybody. ... I did not send the letters," Dutschke said.

Charges were dropped against, Paul Kevin Curtis, 45, the Elvis impersonator, after authorities said they had discovered new information. Curtis' lawyers say he was framed.

Curtis' attorney, Christi McCoy, said Saturday: "We are relieved but also saddened. This crime is nothing short of diabolical. I have seen a lot of meanness in the past two decades, but this stops me in my tracks. "

Dutschke and Curtis were acquainted. Curtis said they had talked about possibly publishing a book on an alleged conspiracy to sell body parts on a black market. But he said they later had a feud.

Judge Holland is a common link between the two men, and both know Wicker.

Holland was the presiding judge in a 2004 case in which Curtis was accused of assaulting a Tupelo attorney a year earlier. Holland sentenced him to six months in the county jail. He served only part of the sentence, according to his brother.

Holland's family has had political skirmishes with Dutschke. Her son, Steve Holland, a Democratic state representative, said he thinks his mother's only other encounter with Dutschke was at a rally in the town of Verona in 2007, when Dutschke ran as a Republican against Steve Holland

Holland said his mother confronted Dutschke after he made a derogatory speech about the Holland family. She demanded that he apologize, which Holland says he did.

On Saturday, Steve Holland said he can't say for certain that Dutschke is the person who sent the letter to his mother but added, "I feel confident the FBI knows what they are doing."

"We're ready for this long nightmare to be over," Holland told The Associated Press.

He said he's not sure why someone would target his mother. Holland said he believes Dutschke would have more reason to target him than his mother.

"Maybe he thinks the best way to get to me is to get to the love of my life, which is my mother," Holland said Saturday.

___

Associated Press writer Jack Elliott Jr. in Jackson contributed to this report.

___

Follow Mohr at http://twitter.com/holbrookmohr.

Source: http://news.yahoo.com/miss-man-charged-suspicious-letters-case-195839113.html

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Friday, April 26, 2013

Israel: OK to check emails of foreigners at border

(AP) ? Israel's attorney general on Wednesday upheld a practice to allow security personnel to read people's email accounts when they arrive at the airport, arguing it prevents militants from entering the country.

The ruling followed an outcry last year when some people trying to enter Israel were ordered to open their emails after hours of interrogation at Israel's Ben-Gurion airport. In one instance, three Palestinian-American women were forbidden from entering after email checks were conducted.

Critics say it primarily targets Muslims and Arabs and appears to be aimed at keeping out visitors who have histories of pro-Palestinian activism, citing a history of such people being turned away from Israel's border crossings.

Security personnel may ask visitors to open their email accounts for inspection if they are perceived as being suspicious, wrote Nadim Aboud of Israel's attorney general office. In a response to the Association for Civil Rights in Israel, he said potential entrants may refuse to allow their emails to be checked, but that would be a factor in deciding whether a person would be allowed to enter the country.

Aboud said the checks were justified because there was an increasing risk of foreigners being involved in militant activity. He said security services could not properly investigate the backgrounds of some potential entrants without the additional check.

A Justice Ministry official said the search was conducted only in "extraordinary cases." He spoke anonymously in line with ministry policy.

The attorney general's office wrote the letter in response to a request for clarification by ACRI after incidents were reported last year, said attorney Lila Margalit of the organization. She said Aboud's response effectively legalized the checks, which could now be challenged only in court.

"It was a concern because of the level of invasion inherent in (checking) a personal email account," Margalit said. "It constitutes a violation of privacy."

She said inside Israel, police could search a person's computer data only with court approval, even if there was a criminal investigation underway.

Israeli officials tend to conduct exhaustive checks on foreigners entering the country, or passing through border crossings they control, if they are deemed suspicious.

It particularly affects people who hope to travel to Palestinian areas of the West Bank. The Palestinians a measure of self-government in the West Bank, a territory east of the Jewish state; but Israel controls entry into those areas.

Such visitors frequently complain that they risk not being allowed into the country if they announce they will visit areas under Palestinian Authority control; but risk being accused of lying if they omit that information to security investigators.

There are no statistics on how many people are refused entry into Israel or through border crossings that Israel controls.

One aspect of the issue is that most people entering Israel obtain visas at the airport or other border crossings. Unlike many countries, Israel does not require people to obtain visas from their embassies in advance of their trips, eliminating possible screening before visitors arrive in Israel.

In contrast, Israelis themselves are required to obtain visas far in advance before visiting many countries. Even the U.S. requires an exhaustive interview process at its embassy in Tel Aviv, and it does not grant visas to all who apply. Iranian-born Israelis, for example, are often refused visas.

The practice of email checks appears to be a step beyond what some Western countries allow, while others permit similar measures.

Germany does not allow such searches. The U.S. Department of Homeland Security has seized computers and other electronic devices from people arriving in the United States to search them.

In a narrow ruling last month, the Ninth U.S. Circuit Court of Appeals ruled that while Customs and Border Protection officers can do "a quick look" at a laptop computer or other equipment, reasonable suspicion is required for a more in-depth forensic exam of electronics. It was not immediately clear if that included email.

___

AP writers Alicia A. Caldwell in Washington and Robert Reid in Berlin contributed.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-24-ML-Israel-Email-Search/id-b1b4bcf4c51d46ed912a424792988f16

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Thursday, April 25, 2013

Ice tubes in polar seas -- 'brinicles' or 'sea stalactites' -- provide clues to origin of life

Apr. 24, 2013 ? Life on Earth may have originated not in warm tropical seas, but with weird tubes of ice -- sometimes called "sea stalactites" -- that grow downward into cold seawater near Earth's poles, scientists are reporting. Their article on these "brinicles" appears in ACS' journal Langmuir.

Bruno Escribano and colleagues explain that scientists know surprisingly little about brinicles, which are hollow tubes of ice that can grow to several yards in length around streamers of cold seawater under pack ice. That's because brinicles are difficult to study. The scientists set out to gather more information on the topic with an analysis of the growth process of brinicles.

They are shown to be analogous to a "chemical garden," a standby demonstration in chemistry classes and children's chemistry sets, in which tubes grow upward from metal salts dropped into silicate solution. But brinicles grow downward from the bottom of the ice pack.

The analysis concluded that brinicles provide an environment that could well have fostered the emergence of life on Earth billions of years ago, and could have done so on other planets. "Beyond Earth, the brinicle formation mechanism may be important in the context of planets and moons with ice-covered oceans," the report states, citing in particular two moons of Jupiter named Ganymede and Callisto.

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The above story is reprinted from materials provided by American Chemical Society.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Julyan Cartwright, Bruno Escribano, Diego L. Gonz?lez, Claro Ignacio Sainz-Diaz, idan tuval. Brinicles as a case of inverse chemical gardens. Langmuir, 2013; : 130403173604005 DOI: 10.1021/la4009703

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/DaSQJwKHSz4/130424112316.htm

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From Battle To Birds: Drones Get Second Life Counting Critters

Researchers are using small remote-controlled planes to survey the populations of the greater sage grouse.

Stephen J. Krasemann/Science Source

Researchers are using small remote-controlled planes to survey the populations of the greater sage grouse.

Stephen J. Krasemann/Science Source

The U.S. military and law enforcement agencies have seen increased public scrutiny on the domestic use of the robotically piloted planes known as drones. Working on the sidelines of this debate, the U.S. Geological Survey has been trying to find a second life for retired military drones in the areas of environmental and wildlife management. Instead of watching the battlefield, these drones are watching birds.

The 4-pound Raven A drone is launched by hand. Researchers hope thermal and photographic imaging from the drones can help accurately estimate animal populations.

Grace Hood/KUNC

Earlier this month, scientists spent three days flying a small 4-pound Raven A drone above the breeding grounds of the greater sage grouse, about 120 miles northwest of Denver. USGS hydrologist Chris Holmquist-Johnson says researchers are trying to figure out if they can use the drone to capture photo and thermal images of the birds without disturbing them.

"So far what we've seen is that they really don't seem to be bothered by it," Homquist-Johnson says. "We're able to get that imagery and they don't flush or move on to a new location."

The experiment is part of a larger project. In recent years, the National Unmanned Aircraft Systems Project Office has coordinated with state and federal agencies to use drones to study everything from mountain pine beetle damage in Colorado to documenting bank erosion along the Missouri River in South Dakota.

The USGS also has had previous success with birds, counting Sandhill Cranes in Monte Vista National Wildlife Refuge in southern Colorado. USGS biologist Leanne Hanson says that in 2011, scientists compared counts from the results of Raven A flights to those of ground observers and found the flight data accurate enough to switch to using drones exclusively in 2012.

In future years, the practice could save federal agencies money, Hanson says. "Our estimates are that it would be a 10th of the cost."

USGS mission operator Jeff Sloan monitors the Raven A's progress. Each flight requires a three-person team that includes a mission operator, observer and pilot.

Grace Hood/KUNC

USGS mission operator Jeff Sloan monitors the Raven A's progress. Each flight requires a three-person team that includes a mission operator, observer and pilot.

Grace Hood/KUNC

Brian Rutledge, executive director of Audubon Rockies, has been watching the population of sage grouse decline for decades across the West. And while he says he's in favor of any technology that might lead to a more accurate count of the species, he doesn't think any machine can entirely replace human observers on the ground.

"This is something that gives us eyes in the sky ? no pun intended ? to find places and creatures that we wouldn't have on record otherwise," he says. "These will give us hints as to where we ought to look, [and] help us understand populations better. They'll never replace somebody with a notebook and a pair of binoculars or a good spotting scope."

Researchers are circumspect about how much they think the remote planes will advance bird counts. Holmquist-Johnson says one limitation comes from the lower resolution cameras and sensors in the Raven A. Overall, experiments with drone technology are still in the very early stages, he says.

"As systems get better and sensors are better, then we'll be able to do an even better job of the science," he says.

The USGS office overseeing these robotic planes gets more than a dozen calls a week from other Interior Department units interested in using them. Upcoming experiments include a climate change study near Niwot, Colo., efforts to count mule deer in Nevada, and a survey of pygmy rabbit habitat in Idaho.

Source: http://www.npr.org/2013/04/25/179017548/from-battle-to-birds-drones-get-second-life-counting-critters?ft=1&f=1007

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Wednesday, April 24, 2013

PLAiR Adds AirPlay-Like Functionality To Any HDTV For $99, Now Available For Sale

HDMI_allPLAiR is a sub-$100, dolphin-shaped dongle for streaming online video to your TV screen, either from a computer or any mobile device. The idea is to enable anyone to experience AirPlay-like functionality, even if they don?t have an Apple TV ? or an iPhone or an iPad. The product debuted at CES and is finally ready to ship to consumers.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/6hNUYJ0Jiy0/

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Cost-cutting gives Credit Suisse a huge Q1 lift

BASEL, Switzerland (AP) ? Swiss bank Credit Suisse Group said Wednesday that its cost-cutting efforts helped it record a huge jump in first-quarter profits compared with a year earlier.

Switzerland's second-biggest bank posted a profit of 1.3 billion Swiss francs ($1.37 billion), up sharply from the 44 million francs in the first quarter of 2012, when it booked a loss of 1.6 billion francs on its own outstanding debt and paid out higher bonuses.

Net revenue rose 6 percent to 7.2 billion francs.

The bank said the figures showed "positive momentum" coming from its attempts to transform its business model, that includes a lot of cost-cutting.

Credit Suisse shares were up 1.2 percent at 26.77 francs in afternoon trading in Zurich.

"The first quarter of 2013 shows that the strategic measures we have successfully implemented since mid-2011 are effective in bringing results to the bottom line on a consistent basis," Chief Executive Brady Dougan said. "We had a very good start to 2013."

The bank, based in Zurich, said the results for the January-March period showed "high returns, strong client franchises, reduced cost base and lower risk-weighted assets."

Like its cross-town and bigger competitor, UBS AG, Credit Suisse has been reducing its riskier assets at a time when Europe's economy is hurting.

Both banks have been setting aside more capital cushion to meet international and domestic regulatory demands. But Credit Suisse has not cut back on its investment banking as much as UBS, and a restructuring in Credit Suisse's investment bank compensated for a falloff in profits from its private banking, one of the largest such operations in the world in terms of assets.

The figures showed further cuts to the bank's workforce to 46,900 people, down 4 percent from 47,400 a year earlier. The downsizing is part of a program that has cut 2.5 billion francs in costs since 2011, and the bank said Wednesday it is on track to extend that to 4.4 billion francs by the end of 2015.

Credit Suisse said Monday it was selling its private equity business, Strategic Partners, which is also based in Zurich, to New York-based Blackstone Group LP for an undisclosed amount.

Strategic Partners manages $9 billion in assets and buys stakes in other private equity funds. The Zurich bank agreed last month to buy Morgan Stanley's wealth management unit, with $13 billion in assets under management, to expand in Europe, the Middle East and Africa.

The bank also said it had no new information about when talks with the Swiss government might wrap up over a U.S. investigation of the bank over suspected American tax cheats.

Source: http://news.yahoo.com/cost-cutting-gives-credit-suisse-huge-q1-lift-134436478--finance.html

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AT&T revenue disappoints as it loses cellphone subscribers

By Sinead Carew

NEW YORK (Reuters) - AT&T Inc reported a net loss of cellphone subscribers in the first quarter as it lost market share to bigger rival Verizon Wireless, sending its shares down about 2 percent.

As a result AT&T's revenue missed Wall Street expectations as its subscriber growth was driven by tablet computer users who pay lower monthly fees than phone users.

Since most U.S. consumers already have smartphones, the No. 2 U.S. mobile service provider and its rivals are rushing to put wireless connections in everything from tablet computers and consumer electronics to medical devices and home security systems.

But while customers with devices like tablets are less costly to attract than smartphone users, which require hefty subsidies, tablet customers bring in less revenue, raising analyst concerns about AT&T's prospects for top-line growth.

"It's going to take so many connected devices to make up for losing a phone subscriber," said Nomura analyst Michael McCormack, adding that slowing phone customer growth is also a concern for smaller rivals such as Sprint Nextel and T-Mobile USA, a unit of Deutsche Telekom.

AT&T maintained its target for 2013 overall revenue growth of 2 percent and said it still expects net additions of phone customers for the full year due to a boost in sales in launch quarters for popular phones like Apple Inc's iPhone.

But Susan Johnson, senior vice president for investor relations, said other devices would be increasingly important.

"It's not just about smartphones any more," Johnson told Reuters in an interview on Tuesday after the company's quarterly conference call during which analysts peppered executives with questions about the net loss of phone customers.

AT&T said it added 296,000 subscribers in the quarter, ahead of Wall Street expectations for just over 195,000, according to six analysts contacted by Reuters. But this included a net addition of 365,000 subscribers using tablet computers, implying a net loss of 69,000 higher-value phone subscribers.

In comparison its bigger rival Verizon Wireless, a venture of Verizon Communications and Vodafone Group Plc, said last week that it added 677,000 subscribers in the first quarter.

Sprint, the No.3 U.S. mobile service provider, is scheduled to report its quarterly earnings on Wednesday.

Nomura's McCormack said AT&T's 0.9 percent growth in average monthly revenue per user (ARPU) missed his expectation for 1.9 percent growth.

"The concern's going to be how we should be thinking about ARPU going forward," the analyst said.

AT&T's revenue fell to $31.36 billion from $31.82 billion in the year-ago quarter, before the company sold its telephone directory business. Analysts, on average, had expected revenue of $31.74 billion, according to Thomson Reuters I/B/E/S.

While AT&T's wireless profitability was better than analysts expected, McCormack said that a 29.5 percent profit margin for its wireline business missed his expectation for 30.4 percent.

AT&T Chief Financial Officer John Stephens told analysts on the conference call that the wireline business was hurt by weak demand from business and customers who are slowing spending due to concerns about the economy.

"The economy continues to be the issue," Stephens said.

AT&T's overall profit rose to $3.7 billion, or 67 cents per share, from $3.58 billion, or 60 cents per share, in the year-ago quarter.

It reported a wireless service margin of 43.2 percent based on earnings before interest, taxes, depreciation and amortization, up from 42.3 percent in the year-ago quarter and beating the six analysts' expectations for 42.3 percent.

On the plus side AT&T cut its capital spending target for 2014 and 2015 to $20 billion each year from its previous expectation for $22 billion as a network upgrade it is working on will cost less than it had previously expected.

The company kept its capital spending budget for 2013 in the $21 billion range.

It ended the quarter with 8.7 million U-verse high-speed Internet and television subscribers. It added 731,000 U-verse Internet subscribers, which was a record for the company, and 232,000 U-verse TV subscribers - its strongest growth rate in nine quarters.

AT&T shares fell about 2 percent to $38.24 in after-hours trade from their $39 close in the regular New York Stock Exchange session.

(Reporting by Sinead Carew; Editing by Jim Marshall, Tim Dobbyn and Phil Berlowitz)

Source: http://news.yahoo.com/t-revenue-disappoints-loses-cellphone-subscribers-002301192--sector.html

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Chartboost Is Building The Next Gaming Platform To Watch, And They're Expanding To Europe

Chartboost-LogoHFive years ago from their native city of Barcelona, Maria Alegre used to watch old Stanford Technology Ventures Program videos from entrepreneurs sharing their founding stories. Intrigued by what she heard, she picked up and moved to the Valley, where Alegre dug into mobile gaming at early developer Tapulous, which went on to be acquired by Disney. Fast forward to today, Alegre is running one of the fastest-growing game discovery platforms and mobile ad networks in Silicon Valley — one that we’ve heard from three separate sources grossed about $50 million last year. (The company doesn’t comment on revenue figures). Her company Chartboost is quietly sucking in talent from an older generation of mobile ad networks and gaming studios like Google’s AdMob, DeNA’s Ngmoco and EA’s Popcap. They also picked up $19 million in funding led by storied VC firm Sequoia earlier this year. “It’s kind of crazy. This all happened in four years,” she said. “Anyone can do it. People running these companies are not super humans. They are just people like you and me.” Today Chartboost is opening its first office abroad in Europe, led by Ilja Goossens, who founded Gamundo and Virtual Fairground. The new location in Amsterdam is meant to strengthen the company’s relationships with the biggest game developers across the continent. Europe is having something of a Renaissance in mobile gaming right now with players like Finland’s Supercell (which made $104 million in profit with just 100 people last quarter), Berlin’s Wooga and London’s King. While other competing startups with mobile advertising products were less focused, Chartboost wedged itself into the gaming world where it built an early platform for developers to trade advertising inventory. Because games are the biggest category for apps in terms of time spent on iOS and Android, it was the ideal place to build a focused business. Chartboost earns revenue through excess inventory, which can be sold in an exchange. Chartboost now has 16,000 games in its network and 8 billion ad impressions per month and has grown 30 percent since January. Instead of the old banner ads, which had poor clickthrough rates, Chartboost instead focused on creating interstitials that looked and felt like they belonged in a game. At first, it wasn’t easy, however. Alegre said that when she and her co-founder Sean Fannan were starting out, they did 30 phone pitches to potential investors in a week. In

Source: http://feedproxy.google.com/~r/Techcrunch/~3/JzRLZE28kjk/

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Tuesday, April 23, 2013

After age 18, asthma care deteriorates

After age 18, asthma care deteriorates [ Back to EurekAlert! ] Public release date: 22-Apr-2013
[ | E-mail | Share Share ]

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

It is widely accepted that medical insurance helps older adults with chronic health problems to receive better care. But what about young adults between the ages of 18 and 25, a demographic that also tends to have the lowest levels of health insurance coverage?

In what may be the first study to measure health care utilization patterns among young adults with chronic health problemsin this case asthmaa team of researchers at Harvard Medical School found that losing health insurance was a significant predictor of deteriorating patterns of health management. Other social factors, including leaving school and losing adult supervision, also contributed to the deterioration.

"This study suggests that expanding insurance coverage will help many young adults with asthma receive the care that they need," said Kao-Ping Chua, a staff physician in the Division of Emergency Medicine at Boston Children's Hospital who led the study. "But it also points to the importance of addressing other socially-mediated factors in this population."

J. Michael McWilliams, HMS assistant professor of health care policy and medicine at Brigham and Women's Hospital was the senior author of the study, to be published April 22 in Pediatrics.

"Aside from the lack of financial protection, uninsurance poses fewer health risks to young adults than for older adults because they are generally healthy," McWilliams said. "But for young people with asthmaor other conditions amenable to medical careit's important to understand and address the barriers to care."

The researchers used nationally representative data from the 1999 to 2009 Medical Expenditure Panel Survey, looking at a sample of 2,485 individuals between the ages of 14 and 25. The researchers investigated how an individual's age related to having a regular care provider, visiting that provider at least once per year, using asthma medications, and visiting the emergency room.

They found that while adolescents under age 18 were more likely to utilize primary care and preventive measures, young adults over age 18 were more likely to use the emergency room and have problems accessing medical care and medications because of cost. Losing insurance explained 32 percent of the decline in use of primary care and 47 to 61 percent of the increase in cost-related access problems.

Under the federal Affordable Care Act health reform law, young people whose parents have private insurance will be eligible to remain covered on their parents' policies until they are 26. The news is not so good for many low-income young people whose parents may be uninsured or receive public assistance. Since the Supreme Court ruled that the ACA could not require states to expand their Medicaid coverage, many states have decided not to expand coverage, and one of the key groups that will likely be left out is low-income young adults.

"We may continue to see particularly poor asthma care for many young adults in states that don't expand their Medicaid programs," McWilliams said.

But increasing insurance coverage alone is not the answer, the researchers said. Health professionals who provide care for children and adolescents with chronic illnesses like asthma have to think about patients who are aging out of their practice, the researchers said.

"Young people with asthma need to work with their care providers to create transition plans from pediatric to adult care that take into account their medical and social history," Chua said.

###

This research was supported by the Harvard Pediatric Health Services Research Fellowship (AHRQ NRSA 5T32HS00063-17), the Beeson Career Development Award Program (National Institute on Aging K08 AG038354 and the American Federation for Aging Research) and Doris Duke Charitable Foundation (Clinical Scientist Development Award #2010053).

Written by Jake Miller

Harvard Medical School has more than 7,500 full-time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital-based clinical departments at 16 Harvard-affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew SeniorLife, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital, and VA Boston Healthcare System.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


After age 18, asthma care deteriorates [ Back to EurekAlert! ] Public release date: 22-Apr-2013
[ | E-mail | Share Share ]

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

It is widely accepted that medical insurance helps older adults with chronic health problems to receive better care. But what about young adults between the ages of 18 and 25, a demographic that also tends to have the lowest levels of health insurance coverage?

In what may be the first study to measure health care utilization patterns among young adults with chronic health problemsin this case asthmaa team of researchers at Harvard Medical School found that losing health insurance was a significant predictor of deteriorating patterns of health management. Other social factors, including leaving school and losing adult supervision, also contributed to the deterioration.

"This study suggests that expanding insurance coverage will help many young adults with asthma receive the care that they need," said Kao-Ping Chua, a staff physician in the Division of Emergency Medicine at Boston Children's Hospital who led the study. "But it also points to the importance of addressing other socially-mediated factors in this population."

J. Michael McWilliams, HMS assistant professor of health care policy and medicine at Brigham and Women's Hospital was the senior author of the study, to be published April 22 in Pediatrics.

"Aside from the lack of financial protection, uninsurance poses fewer health risks to young adults than for older adults because they are generally healthy," McWilliams said. "But for young people with asthmaor other conditions amenable to medical careit's important to understand and address the barriers to care."

The researchers used nationally representative data from the 1999 to 2009 Medical Expenditure Panel Survey, looking at a sample of 2,485 individuals between the ages of 14 and 25. The researchers investigated how an individual's age related to having a regular care provider, visiting that provider at least once per year, using asthma medications, and visiting the emergency room.

They found that while adolescents under age 18 were more likely to utilize primary care and preventive measures, young adults over age 18 were more likely to use the emergency room and have problems accessing medical care and medications because of cost. Losing insurance explained 32 percent of the decline in use of primary care and 47 to 61 percent of the increase in cost-related access problems.

Under the federal Affordable Care Act health reform law, young people whose parents have private insurance will be eligible to remain covered on their parents' policies until they are 26. The news is not so good for many low-income young people whose parents may be uninsured or receive public assistance. Since the Supreme Court ruled that the ACA could not require states to expand their Medicaid coverage, many states have decided not to expand coverage, and one of the key groups that will likely be left out is low-income young adults.

"We may continue to see particularly poor asthma care for many young adults in states that don't expand their Medicaid programs," McWilliams said.

But increasing insurance coverage alone is not the answer, the researchers said. Health professionals who provide care for children and adolescents with chronic illnesses like asthma have to think about patients who are aging out of their practice, the researchers said.

"Young people with asthma need to work with their care providers to create transition plans from pediatric to adult care that take into account their medical and social history," Chua said.

###

This research was supported by the Harvard Pediatric Health Services Research Fellowship (AHRQ NRSA 5T32HS00063-17), the Beeson Career Development Award Program (National Institute on Aging K08 AG038354 and the American Federation for Aging Research) and Doris Duke Charitable Foundation (Clinical Scientist Development Award #2010053).

Written by Jake Miller

Harvard Medical School has more than 7,500 full-time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital-based clinical departments at 16 Harvard-affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew SeniorLife, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital, and VA Boston Healthcare System.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/hms-aa1041713.php

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Too Early to Know Whether Democrats Will Fall Prey to Second-Term Jinx

This early in the 2014 congressional midterm-election cycle, it?s impossible to know what the election will be about?whether there will be a wind in favor of either party and, if so, what the velocity and impact will be. Recently, we have had three back-to-back wave elections, with 2006 and 2008 in favor of Democrats and 2010 benefiting Republicans. While 2012 cannot really be considered a wave, the election did display certain dynamics that benefited Democrats?at least in national races, although not in gubernatorial ones.

It?s important to remember that wave elections are not the norm?they are actually the exception to the rule. The adage by the late Democratic House Speaker Tip O?Neill that ?all politics is local? would more accurately be ?all politics is local, except when it is not.? In the 1980 elections, Ronald Reagan unseated President Carter by a 10 percentage-point margin, and Republicans gained 12 seats in the Senate and 34 in the House; this was the first wave election our country had seen since the 1974 Watergate upheaval. The next true wave election after 1980 was in 1994, during the Newt Gingrich-led Republican takeover of the House, which resulted in a 52-seat gain, accompanied by a strong eight-seat gain in the Senate. (Note: Sen. Richard Shelby of Alabama switched from the Democratic to the GOP the day after the election, bringing the total Republican gain to nine.) After 1994, there was not another wave for 12 years. Then we saw three consecutive wave elections: 2006, 2008, and the reverse wave in 2010, when Republicans were the beneficiaries and Democrats were the victims.

The safer way to look at congressional elections is to start off assuming that any election will be a normal ?all politics is local? situation, while constantly looking closely for signs that it might not be. Keep an eye out for the chance that it turns out to be a wave year, rather than a relatively level battlefield.

Another thing to remember is that just because it?s a ?normal? election doesn?t necessarily mean that it?s a calm one. In any election following a surge or wave election?two years later in the House or six years later in the Senate?there can be a decline or a corrective election, wherein the party that benefited from the wave in the previous election loses some or all of its gains in the next cycle. This can occur not necessarily because there are strong countervailing dynamics against the winning party as much as because certain seats gained in a wave election can?t be held in another election where that party isn?t enjoying the strong, beneficial dynamics of the previous election. In a wave election, many extremely strong, bright, and talented candidates win along with some fairly strong, reasonably intelligent, and somewhat talented candidates. Often, some of the candidates who win in these cycles aren?t that good?they just had the good fortune of running in a terrific year for their party. These candidates woke up on a Wednesday morning and discovered that they had just been elected to Congress, whether they were deserving of it or not. These seats are the ones that are often the first to go in an adverse or even normal election year. The Democratic gains in 1986 serve as a pretty good example of this. While the second-term Reagan White House was dealing with the Iran-Contra scandal?which no doubt sapped some of its strength?the GOP saw losses in the Senate. This can be interpreted as a rebound from some ?exotic? candidates who won on Reagan?s coattails in 1980 but weren?t sufficiently strong to win on their own six years later.

The temptation at this point in an election cycle is to assume that the dynamics that were in place in the last election will just carry forward into the next one. We assume we?ll see the political equivalent of generals who fought in the last war returning for the next one. Occasionally, a party has two or more favorable elections in a row, such as the 1932-34-36 trifecta for Democrats; the years 1974-76 for Democrats; and, of course, 2006-2008 for the Democrats. But that?s three times in the last 40 years?not that frequent of a pattern to depend on.

Coming out of the 2012 elections, the Republican Party is clearly facing some challenges. Some problems are demographic, specifically the damage to its brand among many minority, female, and younger voters. Others are more ideological: To many voters in the middle, the rhetoric and positioning of the GOP in the past few years has been much more off-putting to these nonideological individuals than that of Democrats. It?s important to note that at other times, the shoe is still on the other foot, and Democrats are the offending party to those middle-of-the-road voters.

Finally, Republicans have fallen behind when it comes to campaign technology. They have gone from a state-of-the-art operation in 2004, with the George W. Bush reelection effort led by Karl Rove and Ken Mehlman, to now appearing to be, on a multitude of levels, one, two, or three steps behind their Democratic foes. How long it will take the Republicans to catch up remains to be seen, but campaign-technology experts point out that given the rapid pace of technological change, any advantage by one party is only a temporary edge built on sand. It is not that hard for the other party to catch up or leapfrog ahead.

Historically, we have seen unfortunate political patterns appear during second presidential terms. The party occupying the Oval Office has suffered significant House and/or Senate losses in five of the last six second-term, midterm elections. Since World War II, the party holding the White House for two consecutive terms has also lost it in five out of the six subsequent elections. Will the dominant dynamic be a continuation of earlier problems for the GOP, or will the historical pattern of the second-term jinx hold?

Source: http://news.yahoo.com/too-early-know-whether-democrats-fall-prey-second-221457105--politics.html

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NH tourism industry praises "Live Free" campaign

CONCORD, N.H. (AP) ? The new tourism campaign New Hampshire rolled out a year ago is working so well, state officials are planning to expand it to other areas, including economic development.

The "Live Free and ...." is a fill-in-the-blank play on the state's longstanding "Live Free or Die" motto. The state has used variations including "Live Free and Play," ''Live Free and Explore" in its advertising, and attractions statewide have been putting their own twist on it.

Speaking at a conference Monday, state Travel and Tourism Director Lori Harnois said the campaign has helped boost tourism spending, which increased to $4.4 billion in the last fiscal year. And Jeff Rose, commissioner of the Department of Resources and Economic Development, said he plans to use a similar approach to attract new businesses to the state.

Source: http://news.yahoo.com/nh-tourism-industry-praises-live-free-campaign-042416977.html

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Netflix to Charge $12 to Make Sharing Your Password a Better Experience

Netflix to Charge $12 to Make Sharing Your Password a Better Experience
In today?s first-quarter earnings letter, Netflix announced a $12-a-month plan that doubles the current limit of two simultaneous video streams to four simultaneous feeds plan.

Source: http://feedproxy.google.com/~r/GearFactor/~3/lXoZnZ0BSkQ/

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Study upends model of how dividing cells monitor distribution of chromosomes

Apr. 21, 2013 ? Ludwig researchers Arshad Desai and Christopher Campbell, a post-doctoral fellow in his laboratory, were conducting an experiment to parse the molecular details of cell division about three years ago, when they engineered a mutant yeast cell as a control that, in theory, had no chance of surviving. Apparently unaware of this, the mutant thrived.

Intrigued, Campbell and Desai began exploring how it had defied its predicted fate. As detailed in the current issue of Nature, what they discovered has overturned the prevailing model of how dividing cells ensure that each of their daughter cells emerge with equal numbers of chromosomes, which together package the genome. "Getting the right number of chromosomes into each cell is absolutely essential to sustaining life," explains Desai, PhD, a Ludwig member at the University of California, San Diego, "but it is also something that goes terribly wrong in cancer. The kinds of mistakes that occur when this process isn't functioning properly are seen in about 90% of cancers, and very frequently in advanced and drug-resistant tumors."

Campbell and Desai's study focused in particular on four interacting proteins known as the chromosomal passenger complex (CPC) that monitor the appropriate parceling out of chromosomes. When cells initiate division, each chromosome is made of two connected, identical sister chromatids -- roughly resembling a pair of baguettes joined in the middle. As the process of cell division advances, long protein ropes known as microtubules that extend from opposite ends of the cell hook up to the chromosomes to yank each of the sister chromatids in opposite directions. The microtubules attach to the chromatids via an intricate disc-like structure called the kinetochore. When the protein ropes attach correctly to the sister chromatids, pulling at each from opposing sides, they generate tension on the chromosome. One of the four proteins of the CPC, Aurora B kinase, is an enzyme that monitors that tension. Aurora B is expressed at high levels in many cancers and has long been a target for the development of cancer therapies.

Aurora B is essentially a molecular detector. "If the chromosomes are not under tension," says Desai, "Aurora B forces the rope to release the kinetochore and try attaching over and over again, until they achieve that correct, tense attachment."

The question is how? Aurora B is ordinarily found between the two kinetochores in a region of the chromosome that links the sister chromatids, known as the centromere. The prevailing model held that the microtubule ropes would pull themselves, and the kinetochores, away from Aurora B's reach, so that it cannot force the microtubule ropes to detach from their captive chromosomes. In other words, the location of Aurora B between the two kinetochore discs was thought to be central to its role as a monitor of the requisite tension. "This matter was thought settled," says Desai.

Yet, as Campbell and Desai show through their experiments, yeast cells engineered to carry a mutant CPC that can't be targeted to the centromere survive quite vigorously. They demonstrate that in such cells Aurora B instead congregates on the microtubule ropes. There, it somehow still ensures that the required tension is achieved on chromosomes before they are parceled out to daughter cells.

How precisely it does this remains unclear. Campbell and Desai provide evidence that the clustering of Aurora B on microtubules might be sufficient to activate its function. At the same time, they hypothesize, appropriate tension on the chromosome may induce structural changes in Aurora B's targets that make them resistant to its enzymatic activity. Campbell and Desai are now conducting experiments to test these ideas.

This work was supported by the Ludwig Institute for Cancer Research, the National Institutes of Health (GM074215) and the Damon Runyon Cancer Research Foundation Fellowship (DRG 2007-09).

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The above story is reprinted from materials provided by Ludwig Institute for Cancer Research, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Christopher S. Campbell and Arshad Desai. Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature, 2013 DOI: 10.1038/nature12057

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/sAYVqaJuguw/130421151620.htm

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